Nick Kroll as Nick Birch
Jessi Klein as Jessi Glaser
John Mulaney as Andrew Glouberman
Jenny Slate as Missy Foreman-Greenwald
Jason Mantzoukas as Jay Bilzerian
Fred Armisen as Elliot Birch
Maya Rudolph as Connie the Hormone Monstress
Fred Armisen as Elliot Birch
Jordan Peele as Ghost of Duke Ellington
Paula Pell as Barbara Glouberman
Andrew Rannells as Matthew MacDell
Kat Dennings as Leah Birch
Richard Kind as Marty Glouberman
Seth Morris as Greg Glaser