Gina Rodriguez as Carmen Sandiego
Finn Wolfhard as Player
Abby Trott as Ivy
Micheal Hawley as Zack
Paul Nakauchi as Shadowsan
Liam O'Brien as Professor Gunnar Maelstrom
None as Mime Bomb
Bernardo De Paula as Le Chèvre
Kimiko Glenn as Paper Star
Andrew Pifko as El Topo
Dawnn Lewis as The Chief/Tamara Fraser
Michael Goldsmith as Gray/Crackle/Graham Calloway
Rafael Peteradi as Chase Devineaux
Charlet Chung as Julia Argent
Mary Elizabeth McGlynn as Coach Brunt
Toks Olagundoye as Countess Cleo
Sharon Muthu as Dr. Bellum
Rita Moreno as Cookie Booker
Kari Wahlgren as Sheena/Tigress