Diego Vásquez
as José Arcadio Buendía
Marleyda Soto
as Úrsula Iguarán
Claudio Cataño
as Aureliano Buendía
Marco Gonzales
as José Arcadio Buendía (young)
Susana Morales
as Úrsula Iguarán (young)
Jerónimo Barón Lyentsova
as Aureliano Buendía (child)
Santiago Guzmán
as Aureliano Buendía (adolescent)
Moreno Borja
as Melquiades
Édgar Vittorino
as José Arcadio
Leonardo Soto
as José Arcadio (young)
Viña Machado
as Pilar Ternera
Janer Villarreal
as Arcadio Buendía
Juan Eduardo Florido
as Arcadio Buendía (young)
Loren Sofía Paz
as Amaranta Buendía
Luna Ruiz Jiménez
as Amaranta Buendía (young)
Akima
as Rebeca Buendía
Nicole Montenegro Sánchez
as Rebeca Buendía (young)
Ruggero Pasquarelli
as Pietro Crespi
Jacqueline Arenal
as Leonor Moscote
Jairo Camargo
as Apolinar Moscote
Cristal Aparicio
as Remedios Moscote
Salvador del Solar
as General Moncada