Molly Parker as Maureen Robinson
Toby Stephens as John Robinson
Maxwell Jenkins as Will Robinson
Ignacio Serricchio as Don West
Mina Sundwall as Penny Robinson
Taylor Russell as Judy Robinson
Parker Posey as June Harris / Dr. Smith
Brian Steele as The Robot
Raza Jaffrey as Victor Dhar
Ajay Friese as Vijay Dhar
Sibongile Mlambo as Angela
Kiki Sukezane as Aiko Watanabe
Yukari Komatsu as Naoko Watanabe
Selma Blair as Jessica Harris
Cary-Hiroyuki Tagawa as Hiroki Watanabe