Michael Sheen as Dr. William Masters
Lizzy Caplan as Virginia Johnson
Beau Bridges as Barton Scully
Julianne Nicholson as Dr. Lillian DePaul
Allison Janney as Margaret Scully
Nicholas D'Agosto as Ethan Haas
Caitlin FitzGerald as Libby Masters
Teddy Sears as Dr. Austin Langham
Annaleigh Ashford as Betty DiMello
Jaeden Martell as Johnny Masters
Josh Charles as Dan Logan
Betty Gilpin as Nancy Leveau
Jeremy Strong as Dr. Art Dreesen
Nick Clifford as Guy
Kevin Christy as Lester Linden