Wagner Moura as Pablo Escobar
Damián Alcázar as Gilberto Rodríguez Orejuela
Alberto Ammann as Pacho Herrera
Francisco Denis as Miguel Rodríguez Orejuela
Pêpê Rapazote as Chepe Santacruz Londoño
Pedro Pascal as Javier Peña
Ana de la Reguera as Elisa Alvarez
Stephanie Sigman as Valeria Velez
Joanna Christie as Connie Murphy
Maurice Compte as Horacio Carrillo
Juan Pablo Raba as Gustavo Gaviria
Boyd Holbrook as Steve Murphy
Juan Sebastián Calero as Navegante
Matias Varela as Jorge Salcedo
Javier Cámara as Guillermo Pallomari
Matt Whelan as Daniel Van Ness
Michael Stahl-David as Chris Feistl
Arturo Castro as David Rodriguez
Paulina García as Hermilda Gaviria
Germán Jaramillo as Gustavo De Greiff
Juan Pablo Shuk as Hugo Martínez
Sebastián Vega as Hugo Martinez Jr.
Raúl Méndez as Presidente Gaviria
Luis Guzmán as Gacha
André Mattos as Jorge Ochoa
Paulina Gaitan as Tata Escobar
Jorge A. Jimenez as Poison
Danielle Kennedy as Ambassador Noonan