Diego Luna as Miguel Ángel Félix Gallardo
Scoot McNairy as Walt Breslin
José María Yazpik as Amado Carrillo Fuentes
Matt Letscher as James Kuykendall
Alejandro Edda as Joaquín 'El Chapo' Guzmán
Fernanda Urrejola as María Elvira
Teresa Ruiz as Isabella Bautista
Gerardo Taracena as Pablo Acosta Villarreal
Julio Cesar Cedillo as Guillermo González Calderoni
Alfonso Dosal as Benjamín Arellano Félix
Mayra Hermosillo as Enedina Arellano Félix
Manuel Masalva as Ramón Arellano Félix
Miguel Rodarte as Danilo Garza
Jesse Garcia as Sal Orozco
Matt Biedel as Daryl Petsky
Jero Medina as Ossie Mejía
Alberto Zeni as Amat Palacios
Gorka Lasaosa as Héctor Luis Palma Salazar
Andres Londono as Enrique Clavel
Michael Peña as Enrique 'Kiki' Camarena
Tenoch Huerta as Rafael Caro Quintero
Alyssa Diaz as Mika Camarena
Joaquín Cosío as Ernesto 'Don Neto' Fonseca Carrillo
Ernesto Alterio as Salvador Osuna Nava
Aaron Staton as Butch Sears
Lenny Jacobson as Roger Knapp
Tessa Ia as Sofia Conesa
Sosie Bacon as Mimi Webb Miller
Jesús Ochoa as Juan Nepomuceno Guerra