Matthew Rhys as Perry Mason
Shea Whigham as Pete Strickland
Eric Lange as Gene Holcomb
Juliet Rylance as Della Street
Chris Chalk as Paul Drake
Tatiana Maslany as Sister Alice McKeegan
John Lithgow as Elias Birchard “E.B.” Jonathan
Gayle Rankin as Emily Dodson
Andrew Howard as Detective Ennis
Diarra Kilpatrick as Clara Drake
Justin Kirk as Hamilton Burger
Katherine Waterston as Ginny Aimes
Jen Tullock as Anita St. Pierre