Wentworth Miller as Michael J. Scofield
Dominic Purcell as Lincoln Burrows
Robert Knepper as Theodore "T-Bag" Bagwell
Amaury Nolasco as Fernando Sucre
Sarah Wayne Callies as Sara Tancredi
Wade Williams as Bradley Bellick
William Fichtner as Alexander "Alex" Mahone
Paul Adelstein as Paul Kellerman
Rockmond Dunbar as Benjamin Miles “C-Note” Franklin
Jodi Lyn O'Keefe as Gretchen Morgan (Susan B. Anthony)
Leon Russom as General Jonathan Krantz
Marshall Allman as LJ Burrows
Robin Tunney as Veronica Donovan
Stacy Keach as Warden Henry Pope
Michael Rapaport as Don Self
Peter Stormare as John Abruzzi