Melissa Benoist as Kara Danvers / Supergirl
Chyler Leigh as Alex Danvers / Sentinel
David Harewood as Hank Henshaw / Martian Manhunter
Katie McGrath as Lena Luthor
Jesse Rath as Querl 'Brainy' Dox
Nicole Maines as Nia Nal / Dreamer
Azie Tesfai as Kelly Olsen / Guardian
Julie Gonzalo as Andrea Rojas / Acrata
Staz Nair as William Dey
Peta Sergeant as Nyxlygsptlnz
Mehcad Brooks as James Olsen / Guardian
Jeremy Jordan as Winslow 'Winn' Schott Jr. / Toyman
Calista Flockhart as Cat Grant
Floriana Lima as Maggie Sawyer
Chris Wood as Mon-El
Odette Annable as Samantha 'Sam' Arias / Reign
Sam Witwer as Benjamin 'Ben' Lockwood
April Parker Jones as Lauren Haley
Andrea Brooks as Eve Teschmacher
LaMonica Garrett as Mar Novu / Monitor
Jon Cryer as Lex Luthor
Peter Facinelli as Maxwell Lord
Brenda Strong as Lillian Luthor
Sharon Leal as M'gann M'orzz