Bruce Greenwood as Roderick Usher
Mary McDonnell as Madeline Usher
Henry Thomas as Frederick Usher
Samantha Sloyan as Tamerlane Usher
T'Nia Miller as Victorine LaFourcade
Rahul Kohli as Napoleon "Leo" Usher
Kate Siegel as Camille L'Espanaye
Sauriyan Sapkota as Prospero "Perry" Usher
Mark Hamill as Arthur Pym
Carl Lumbly as C. Auguste Dupin
Carla Gugino as Verna
Ruth Codd as Juno Usher
Kyliegh Curran as Lenore Usher
Crystal Balint as Morella Usher
Willa Fitzgerald as Young Madeline Usher
Zach Gilford as Young Roderick Usher
Malcolm Goodwin as Young C. Auguste Dupin
Katie Parker as Annabel Lee
Annabeth Gish as Eliza
Michael Trucco as Rufus Wilmot Griswold