Kyle MacLachlan as Dale Cooper
Michael Ontkean as Harry S. Truman
Sherilyn Fenn as Audrey Horne
Lara Flynn Boyle as Donna Hayward
Mädchen Amick as Shelly Johnson
Ray Wise as Leland Palmer
Kimmy Robertson as Lucy Moran
Catherine E. Coulson as Margaret Lanterman / The Log Lady
Sheryl Lee as Laura Palmer
David Lynch as Gordon Cole
Peggy Lipton as Norma Jennings
Dana Ashbrook as Bobby Briggs
James Marshall as James Hurley
Everett McGill as Ed Hurley
Jack Nance as Pete Martell
Joan Chen as Josie Packard
Sheryl Lee as Maddy Ferguson
Warren Frost as Will Hayward
Piper Laurie as Catherine Martell
Michael Horse as Tommy 'Hawk' Hill
Harry Goaz as Andy Brennan
Eric DaRe as Leo Johnson
Wendy Robie as Nadine Hurley
Russ Tamblyn as Lawrence Jacoby
Frank Silva as BOB
Kenneth Welsh as Windom Earle
Chris Mulkey as Hank Jennings
Gary Hershberger as Mike Nelson
Grace Zabriskie as Sarah Palmer
David Patrick Kelly as Jerry Horne
Ian Buchanan as Richard Tremayne
Michael Parks as Jean Renault
Carel Struycken as The Giant
Miguel Ferrer as Albert Rosenfield
Don S. Davis as Garland Briggs
Al Strobel as MIKE / Phillip Gerard