Hugh Laurie as Gregory House
Robert Sean Leonard as James Wilson
Lisa Edelstein as Lisa Cuddy
Jesse Spencer as Robert Chase
Omar Epps as Eric Foreman
Peter Jacobson as Chris Taub
Jennifer Morrison as Allison Cameron
Kal Penn as Lawrence Kutner
Olivia Wilde as Remy "Thirteen" Hadley
Anne Dudek as Amber Volakis
Amber Tamblyn as Martha M. Masters
Charlyne Yi as Chi Park
Odette Annable as Jessica Adams
Sela Ward as Stacy Warner