Nathan Fillion as 42
Alan Tudyk as Dr. Harry Vanderspeigle
Sara Tomko as Asta Twelvetrees
Alice Wetterlund as D'arcy Bloom
Corey Reynolds as Mike Thompson
Judah Prehn as Max Hawthorne
Levi Fiehler as Ben Hawthorne
Gracelyn Awad-Rinke as Sahar
Elizabeth Bowen as Deputy Sheriff Liv Baker
Ben Cotton as Jimmy
Meredith Garretson as Kate Hawthorne
Kaylayla Raine as Jay
Jenna Lamia as Judy Cooper
Gary Farmer as Dan Twelvetrees
Diana Bang as Nurse Ellen
Michael Cassidy as Dr. Ethan Stone
Mandell Maughan as Lisa Casper
Alex Barima as David Logan
Edi Patterson as Heather
Enver Gjokaj as Joseph Rainier