Dominic West as Jimmy McNulty
Wendell Pierce as Det. William 'Bunk' Moreland
Sonja Sohn as Det. Shakima 'Kima' Greggs
Clarke Peters as Detective Lester Freamon
Michael Kenneth Williams as Omar Little
Deirdre Lovejoy as Rhonda Pearlman
Wood Harris as Avon Barksdale
Andre Royo as Bubbles
Lance Reddick as Colonel Cedric Daniels
Lawrence Gilliard Jr. as D'Angelo Barksdale
John Doman as William A. Rawls
Frankie Faison as Deputy Commissioner Ervin H. Burrell
Chris Bauer as Frank Sobotka
Aidan Gillen as Councilman Thomas 'Tommy' Carcetti
Jim True-Frost as Roland "Prez" Pryzbylewski
Idris Elba as Stringer Bell
Domenick Lombardozzi as Thomas "Herc" Hauk
Robert Wisdom as Howard 'Bunny' Colvin
Amy Ryan as Officer Beatrice "Beadie" Russell
Seth Gilliam as Sergeant Ellis Carver
J.D. Williams as Preston 'Bodie' Broadus
Corey Parker Robinson as Leander Sydnor
Chad L. Coleman as Dennis "Cutty" Wise
Jamie Hector as Marlo Stanfield
Gbenga Akinnagbe as Chris Partlow
Neal Huff as Chief of Staff Michael Steintorf
Jermaine Crawford as Duquan "Dukie" Weems
Tristan Mack Wilds as Michael Lee
Isiah Whitlock Jr. as State Senator R. Clayton "Clay" Davis
James Ransone as Chester 'Ziggy' Sobotka
Bill Raymond as The Greek
Charley Scalies as Thomas 'Horseface' Pakusa
Pablo Schreiber as Nick Sobotka
Chris Ashworth as Sergei "Serge" Malatov
Delaney Williams as Sergeant Jay Landsman
Brian Anthony Wilson as Detective Vernon Holley
Gregory L. Williams as Detective Michael Crutchfield
Robert F. Chew as Proposition Joe Stewart
Method Man as Calvin "Cheese" Wagstaff
Anwan Glover as Slim Charles
Hassan Johnson as Roland "Wee-Bey" Brice
Tom McCarthy as Scott Templeton
David Costabile as Managing Editor Thomas Klebanow
Julito McCullum as Namond Brice
Maestro Harrell as Randy Wagstaff
Michael B. Jordan as Wallace
Christopher Mann as Councilman Anthony 'Tony' Gray